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Département de pathologie et biologie cellulaire

Travaux récents en BIOLOGIE CELLULAIRE, CANCÉROLOGIE ET NEUROSCIENCES

 

Psammomys obesus, a particularly important animal model for the study of the human diabetic nephropathy.
Scherzer P, Katalan S, Got G, Pizov G, Londono I, Gal-Moscovici A, Popovtzer MM, Ziv E, Bendayan M.
Anat Cell Biol. 2011 Sep;44(3):176-85. Epub 2011 Sep 29.

Compartmentalization of pancreatic secretory zymogen granules as revealed by low-voltage transmission electron microscopy.
Bendayan M, Londono I, Paransky E.
J Histochem Cytochem. 2011 Oct;59(10):899-907. Epub 2011 Aug 10.

Essential role of clusterin in pancreas regeneration.
Lee S, Hong SW, Min BH, Shim YJ, Lee KU, Lee IK, Bendayan M, Aronow BJ, Park IS.
Dev Dyn. 2011 Mar;240(3):605-15. doi: 10.1002/dvdy.22556. Epub 2011 Feb 2.

Caspase-3-dependent export of TCTP: a novel pathway for antiapoptotic intercellular communication.
Sirois I, Raymond MA, Brassard N, Cailhier JF, Fedjaev M, Hamelin K, Londono I, Bendayan M, Pshezhetsky AV, Hébert MJ.
Cell Death Differ. 2011 Mar;18(3):549-62. Epub 2010 Oct 22.

Targeting the oncogene eIF4E in cancer: from the bench to clinical trials.
Borden KL.
Clin Invest Med. 2011 Dec 1;34(6):E315.

Ribavirin treatment effects on breast cancers overexpressing eIF4E, a biomarker with prognostic specificity for luminal B-type breast cancer.
Pettersson F, Yau C, Dobocan MC, Culjkovic-Kraljacic B, Retrouvey H, Puckett R, Flores LM, Krop IE, Rousseau C, Cocolakis E, Borden KL, Benz CC, Miller WH Jr.
Clin Cancer Res. 2011 May 1;17(9):2874-84. Epub 2011 Mar 17.

Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway.
Déléris P, Trost M, Topisirovic I, Tanguay PL, Borden KL, Thibault P, Meloche S.
J Biol Chem. 2011 Feb 25;286(8):6470-8. Epub 2010 Dec 22.

Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand.
Ochoa-Sanchez R, Comai S, Lacoste B, Bambico FR, Dominguez-Lopez S, Spadoni G, Rivara S, Bedini A, Angeloni D, Fraschini F, Mor M, Tarzia G, Descarries L, Gobbi G.
J Neurosci. 2011 Dec 14;31(50):18439-52.

Organelle proteomics.
Duclos S, Desjardins M.
Methods Mol Biol. 2011;753:117-28.

Alternative pathways for MHC class I presentation: a new function for autophagy.
Chemali M, Radtke K, Desjardins M, English L.
Cell Mol Life Sci. 2011 May;68(9):1533-41. Epub 2011 Mar 10. Review.

The endosomal proteome of macrophage and dendritic cells.
Duclos S, Clavarino G, Rousserie G, Goyette G, Boulais J, Camossetto V, Gatti E, LaBoissière S, Pierre P, Desjardins M.
Proteomics. 2011 Mar;11(5):854-64. doi: 10.1002/pmic.201000577. Epub 2011 Jan 31.

A cell-permeable phosphine-borane complex delays retinal ganglion cell death after axonal injury through activation of the pro-survival extracellular signal-regulated kinases 1/2 pathway.
Almasieh M, Lieven CJ, Levin LA, Di Polo A.
J Neurochem. 2011 Sep;118(6):1075-86. doi: 10.1111/j.1471-4159.2011.07382.x. Epub 2011 Aug 12.

Identification and characterization of novel rare mutations in the planar cell polarity gene PRICKLE1 in human neural tube defects.
Bosoi CM, Capra V, Allache R, Trinh VQ, De Marco P, Merello E, Drapeau P, Bassuk AG, Kibar Z.
Hum Mutat. 2011 Dec;32(12):1371-5.

FUS and TARDBP but not SOD1 interact in genetic models of amyotrophic lateral sclerosis.
Kabashi E, Bercier V, Lissouba A, Liao M, Brustein E, Rouleau GA, Drapeau P.
PLoS Genet. 2011 Aug;7(8):e1002214. Epub 2011 Aug 4.

Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia.
Gauthier J, Siddiqui TJ, Huashan P, Yokomaku D, Hamdan FF, Champagne N, Lapointe M, Spiegelman D, Noreau A, Lafrenière RG, Fathalli F, Joober R, Krebs MO, DeLisi LE, Mottron L, Fombonne E, Michaud JL, Drapeau P, Carbonetto S, Craig AM, Rouleau GA.
Hum Genet. 2011 Oct;130(4):563-73. Epub 2011 Mar 22.

A novel hypomorphic Looptail allele at the planar cell polarity Vangl2 gene.
Guyot MC, Bosoi CM, Kharfallah F, Reynolds A, Drapeau P, Justice M, Gros P, Kibar Z.
Dev Dyn. 2011 Apr;240(4):839-49. doi: 10.1002/dvdy.22577. Epub 2011 Feb 18.

Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability.
Hamdan FF, Gauthier J, Araki Y, Lin DT, Yoshizawa Y, Higashi K, Park AR, Spiegelman D, Dobrzeniecka S, Piton A, Tomitori H, Daoud H, Massicotte C, Henrion E, Diallo O; S2D Group, Shekarabi M, Marineau C, Shevell M, Maranda B, Mitchell G, Nadeau A, D'Anjou G, Vanasse M, Srour M, Lafrenière RG, Drapeau P, Lacaille JC, Kim E, Lee JR, Igarashi K, Huganir RL, Rouleau GA, Michaud JL.
Am J Hum Genet. 2011 Mar 11;88(3):306-16. Epub 2011 Mar 3. Erratum in: Am J Hum Genet. 2011 Apr 8;88(4):516.

Zebrafish models for the functional genomics of neurogenetic disorders.
Kabashi E, Brustein E, Champagne N, Drapeau P.
Biochim Biophys Acta. 2011 Mar;1812(3):335-45. Epub 2010 Sep 29. Review.

Dual RAS Blockade Normalizes Angiotensin-Converting Enzyme-2 Expression, Prevents Hypertension and Tubular Apoptosis in Akita Angiotensinogen-Transgenic Mice.
Lo CS, Liu F, Shi Y, Maachi H, Chenier I, Godin N, Filep JG, Ingelfinger JR, Zhang SL, Chan JS.
Am J Physiol Renal Physiol. 2011 Dec 28. [Epub ahead of print]

Regulation of neutrophil survival/apoptosis by Mcl-1.
Milot E, Filep JG.
ScientificWorldJournal. 2011;11:1948-62. Epub 2011 Oct 26.

C-reactive protein-derived peptide 201-206 inhibits neutrophil adhesion to endothelial cells and platelets through CD32.
El Kebir D, Zhang Y, Potempa LA, Wu Y, Fournier A, Filep JG.
J Leukoc Biol. 2011 Dec;90(6):1167-75. Epub 2011 Sep 20.

HCaRG accelerates tubular repair after ischemic kidney injury.
Matsuda H, Lavoie JL, Gaboury L, Hamet P, Tremblay J.
J Am Soc Nephrol. 2011 Nov;22(11):2077-89. Epub 2011 Sep 15.

Microcalcifications around a collagen-based breast biopsy marker: complication of biopsy with a percutaneous marking system.
Trop I, David J, El Khoury M, Gautier N, Gaboury L, Lalonde L.
AJR Am J Roentgenol. 2011 Aug;197(2):W353-7.

Co-encapsulation of magnetic nanoparticles and doxorubicin into biodegradable microcarriers for deep tissue targeting by vascular MRI navigation.
Pouponneau P, Leroux JC, Soulez G, Gaboury L, Martel S.
Biomaterials. 2011 May;32(13):3481-6. Epub 2011 Feb 18.

A two-locus system controls susceptibility to colitis-associated colon cancer in mice.
Van Der Kraak L, Meunier C, Turbide C, Jothy S, Gaboury L, Marcus V, Chang SY, Beauchemin N, Gros P.
Oncotarget. 2010 Oct;1(6):436-46.

SMAD3 prevents graft-versus-host disease by restraining Th1 differentiation and granulocyte-mediated tissue damage.
Giroux M, Delisle JS, Gauthier SD, Heinonen KM, Hinsinger J, Houde B, Gaboury L, Brochu S, Wu J, Hébert MJ, Perreault C.
Blood. 2011 Feb 3;117(5):1734-44. Epub 2010 Nov 30.

CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model.
Hassan S, Buchanan M, Jahan K, Aguilar-Mahecha A, Gaboury L, Muller WJ, Alsawafi Y, Mourskaia AA, Siegel PM, Salvucci O, Basik M.
Int J Cancer. 2011 Jul 1;129(1):225-32. doi: 10.1002/ijc.25665. Epub 2010 Nov 12.

Fetal and perinatal autopsy in prenatally diagnosed fetal abnormalities with normal karyotype.
Désilets V, Oligny LL; Genetics Committee of the Society of Obstetricians and Gynaecology Canada; Family Physicians Advisory Committee; Medico–Legal Committee of the SOGC.
J Obstet Gynaecol Can. 2011 Oct;33(10):1047-57. Review.

PAR-4/LKB1 mobilizes nonmuscle myosin through anillin to regulate C. elegans embryonic polarization and cytokinesis.
Chartier NT, Salazar Ospina DP, Benkemoun L, Mayer M, Grill SW, Maddox AS, Labbé JC.
Curr Biol. 2011 Feb 22;21(4):259-69. Epub 2011 Jan 27.

Correlation of intercentromeric distance, mosaicism, and sexual phenotype: molecular localization of breakpoints in isodicentric Y chromosomes.
Bergeron MB, Brochu P, Lemyre E, Lemieux N.
Am J Med Genet A. 2011 Nov;155A(11):2705-12. doi: 10.1002/ajmg.a.34260. Epub 2011 Sep 30.

Undifferentiated Gonadal Tissue, Y Chromosome Instability, and Tumors in XY Gonadal Dysgenesis.
Bergeron MB, Lemieux N, Brochu P.
Pediatr Dev Pathol. 2011 Nov-Dec;14(6):445-59. Epub 2011 Jun 21.

Identification of new susceptibility regions for X;Y translocations in patients with testicular disorder of sex development.
Beaulieu Bergeron M, Lemyre E, Lemieux N.
Sex Dev. 2011;5(1):1-6. Epub 2010 Nov 17.

In vitro nuclear egress of herpes simplex virus type 1 capsids.
Rémillard-Labrosse G, Lippé R.
Methods. 2011 Oct;55(2):153-9. Epub 2011 Jul 30.

The blood-testis barrier: the junctional permeability, the proteins and the lipids.
Pelletier RM.
Prog Histochem Cytochem. 2011 Aug;46(2):49-127. Epub 2011 Jun 25. Review.

CX43 expression, phosphorylation, and distribution in the normal and autoimmune orchitic testis with a look at gap junctions joining germ cell to germ cell.
Pelletier RM, Akpovi CD, Chen L, Day R, Vitale ML.
Am J Physiol Regul Integr Comp Physiol. 2011 Jan;300(1):R121-39. Epub 2010 Oct 20.

The exon junction complex: a splicing factor for long intron containing transcripts?
Ashton-Beaucage D, Therrien M.
Fly (Austin). 2011 Jul-Sep;5(3):224-33. Epub 2011 Jul 1.

Myosin IIB deficiency in embryonic fibroblasts affects regulators and core members of the par polarity complex.
Solinet S, Akpovi CD, Garcia CJ, Barry A, Vitale ML.
Histochem Cell Biol. 2011 Sep;136(3):245-66. doi: 10.1007/s00418-011-0840-0. Epub 2011 Jul 23.

DNA-binding properties of Smc6, a core component of the Smc5-6 DNA repair complex.
Roy MA, D'Amours D.
Biochem Biophys Res Commun. 2011 Dec 9;416(1-2):80-5. Epub 2011 Nov 6.

Independent modulation of the kinase and polo-box activities of Cdc5 protein unravels unique roles in the maintenance of genome stability.
Ratsima H, Ladouceur AM, Pascariu M, Sauvé V, Salloum Z, Maddox PS, D'Amours D.
Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):E914-23. Epub 2011 Oct 10.

Dynamic and selective DNA-binding activity of Smc5, a core component of the Smc5-Smc6 complex.
Roy MA, Siddiqui N, D'Amours D.
Cell Cycle. 2011 Feb 15;10(4):690-700. Epub 2011 Feb 15.

The inositol 5-phosphatase dOCRL controls PI(4,5)P2 homeostasis and is necessary for cytokinesis.
Ben El Kadhi K, Roubinet C, Solinet S, Emery G, Carréno S.
Curr Biol. 2011 Jun 21;21(12):1074-9. Epub 2011 Jun 9.

Structure, assembly and reading of centromeric chromatin.
Maddox PS, Corbett KD, Desai A.
Curr Opin Genet Dev. 2011 Dec 16. [Epub ahead of print]

Asymmetrical segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2.
Ting SB, Deneault E, Hope K, Cellot S, Chagraoui J, Mayotte N, Dorn JF, Laverdure JP, Harvey M, Hawkins ED, Russell SM, Maddox PS, Iscove NN, Sauvageau G.
Blood. 2011 Dec 14. [Epub ahead of print]

Histone H3 lysine 56 acetylation and the response to DNA replication fork damage.
Wurtele H, Kaiser GS, Bacal J, St-Hilaire E, Lee EH, Tsao S, Dorn J, Maddox P, Lisby M, Pasero P, Verreault A.
Mol Cell Biol. 2012 Jan;32(1):154-72. Epub 2011 Oct 24.

Cell size: chromosomes get slapped by a midzone ruler.
Ladouceur AM, Ranjan R, Maddox PS.
Curr Biol. 2011 May 24;21(10):R388-90.

Cytokinesis: cells go back and forth about division.
Dorn JF, Maddox AS.
Curr Biol. 2011 Oct 25;21(20):R848-50.

Cytokinesis, ploidy and aneuploidy.
Lacroix B, Maddox AS.
J Pathol. 2012 Jan;226(2):338-51. doi: 10.1002/path.3013. Epub 2011 Nov 14. Review.

Therapeutic Efficacy of Cord Blood-Derived Mesenchymal Stromal Cells for the Prevention of Acute Graft-Versus-Host Disease in a Xenogenic Mouse Model.
Gregoire-Gauthier J, Selleri S, Fontaine F, Dieng MM, Patey N, Despars G, Beauséjour CM, Haddad E.
Stem Cells Dev. 2011 Oct 21. [Epub ahead of print]

Esophageal squamous papilloma in children.
Rebeuh J, Willot S, Bouron-Dal Soglio D, Patey N, Herzog D, Faure C.
Endoscopy. 2011;43 Suppl 2 UCTN:E256. Epub 2011 Aug 11. No abstract available.

Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases.
Cargnello M, Roux PP.
Microbiol Mol Biol Rev. 2011 Mar;75(1):50-83. Review.

ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1).
Carriere A, Romeo Y, Acosta-Jaquez HA, Moreau J, Bonneil E, Thibault P, Fingar DC, Roux PP.
J Biol Chem. 2011 Jan 7;286(1):567-77. Epub 2010 Nov 11.

Paving the way for targeting RSK in cancer.
Romeo Y, Roux PP.
Expert Opin Ther Targets. 2011 Jan;15(1):5-9. Epub 2010 Oct 19.

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.
Julien LA, Carriere A, Moreau J, Roux PP.
Mol Cell Biol. 2010 Feb;30(4):908-21. Epub 2009 Dec 7.

Molecular networks linked by Moesin drive remodeling of the cell cortex during mitosis.
Roubinet C, Decelle B, Chicanne G, Dorn JF, Payrastre B, Payre F, Carreno S.
J Cell Biol. 2011 Oct 3;195(1):99-112.

Aging of the subventricular zone neural stem cell niche: evidence for quiescence-associated changes between early and mid-adulthood.
Bouab M, Paliouras GN, Aumont A, Forest-Bérard K, Fernandes KJ.
Neuroscience. 2011 Jan 26;173:135-49. Epub 2010 Nov 18.

Distinct stages of adult hippocampal neurogenesis are regulated by running and the running environment.
Bednarczyk MR, Hacker LC, Fortin-Nunez S, Aumont A, Bergeron R, Fernandes KJ.
Hippocampus. 2011 Dec;21(12):1334-47. doi: 10.1002/hipo.20831. Epub 2010 Jul 9.

Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A.
Joyal JS, Sitaras N, Binet F, Rivera JC, Stahl A, Zaniolo K, Shao Z, Polosa A, Zhu T, Hamel D, Djavari M, Kunik D, Honoré JC, Picard E, Zabeida A, Varma DR, Hickson G, Mancini J, Klagsbrun M, Costantino S, Beauséjour C, Lachapelle P, Smith LE, Chemtob S, Sapieha P.
Blood. 2011 Jun 2;117(22):6024-35. Epub 2011 Feb 25.

Restless legs syndrome-associated MEIS1 risk variant influences iron homeostasis.
Catoire H, Dion PA, Xiong L, Amari M, Gaudet R, Girard SL, Noreau A, Gaspar C, Turecki G, Montplaisir JY, Parker JA, Rouleau GA.
Ann Neurol. 2011 Jul;70(1):170-5. doi: 10.1002/ana.22435. Epub 2011 Jun 27.

A mutation in the RNF170 gene causes autosomal dominant sensory ataxia.
Valdmanis PN, Dupré N, Lachance M, Stochmanski SJ, Belzil VV, Dion PA, Thiffault I, Brais B, Weston L, Saint-Amant L, Samuels ME, Rouleau GA.
Brain. 2011 Feb;134(Pt 2):602-7. Epub 2010 Nov 28.

TRPM7 is required within zebrafish sensory neurons for the activation of touch-evoked escape behaviors.
Low SE, Amburgey K, Horstick E, Linsley J, Sprague SM, Cui WW, Zhou W, Hirata H, Saint-Amant L, Hume RI, Kuwada JY.
J Neurosci. 2011 Aug 10;31(32):11633-44.

Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis.
Kobayashi T, Tsang WY, Li J, Lane W, Dynlacht BD.
Cell. 2011 Jun 10;145(6):914-25. Epub 2011 May 27.


© Département de pathologie et biologie cellulaire, 2014