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Département de pathologie et biologie cellulaire

 

Dr Luc Laurier Oligny

Recherche en biologie du cancer

Titre:  Pathologie pédiatrique et foetopathologie

Professeur titulaire, Département de pathologie et biologie cellulaire

Université de Montréal

Hôpital Sainte-Justine
Téléphone : (514) 345-4931 poste 5348

Courriel : luc.laurier.oligny@umontreal.ca

Intérêts de recherche

  • Facteurs pronostiques, incluant le rôle des gènes IGF2 et P53, dans l'évolution des carcinomes corticusurrénaliens pédiatriques.
  • La mutation du gène RET dans le carcinome médullaire de la thyroïde.
  • Rôle d'IGF2 dans le syndrome de Beckwith-Wiedemann et rapprochements entre ce syndrome et la triploïde.
  • Infection au Virus du Papillome Humain: dépistage et caractérisation par séquençage direct dans les biopsies.
  • Morphométrie placentaire et retard de croissance foetale.
  • Épigenèse et cancer.
  • Embryologie moléculaire.

Publications

1) Livres, brochures, rapports à des organismes gouvernementaux ou autres

  • Oligny LL. Essentiel d'embryologie humaine et principes d'embryogenèse moléculaire. Publié et édité annuellement. Montréal, Canada : Faculté de médecine de l'Université de Montréal (plus de 150 pages avec plus de 100 diagrammes originaux en couleurs).
  • Oligny LL. Human Molecular Embryogenesis – An Introduction with emphasis on its relevance to oncogenesis. Publié par les presses de la Society for Pediatric Pathology, avril 2000 (98 pages dont plus de 150 diagrammes originaux en couleurs).
  • Oligny LL. Human Embryology – A Morphologic and molecular primer (titre provisoire). Négociations pour publication en cours.
  • Potter's Pathology of the Fetus and Infant, 2e édition. Édité par Enid Gilbert-Barness, Raj Kapur, Luc L. Oligny et Joseph Siebert. Publié par Mosby-Elsevier (2245 pages, 2007).

 

2) Chapitres de livres

  • Seemayer TA, Oligny LL, Gartner JG. The Epstein-Barr Virus : Historical, Biologic, Pathologic and Oncologic Considerations. In : HS Rosenberg et J. Bernstein, eds. Perspectives in Pediatric Pathology. Masson Publishers, 1981; 6:1-33.
  • Oligny LL. Molecular Embryogenesis – An overview. In : DK Kalousek et JE Dimmick, eds. Perspectives in Pediatric Pathology. Springer Publishers, 2003; Vol. 24, p. 19-38.
  • Potter's pathology of the Fetus and Infant, Chapitre 1: Oligny LL et Wilson GN: Mechanisms of development and growth: Molecular genetics.
  • Potter's pathology of the Fetus and Infant, Chapitre 6: Oligny LL et Kalousek DK: Pathology of abortion: The embryo and previable fetus.
  • Potter's pathology of the Fetus and Infant, Chapitre 5: Oligny LL et Gilbert-Barness E: Chromosomal abnormalities.
  • Potter's pathology of the Fetus and Infant, Chapitre 21: Oligny LL: Thoracoabdominal disorders.

 

3) Publications de recherche ou d'érudition dans des revues dotées de Comités de pairs

  • Seemayer TA, Oligny LL, Tannenbaum GS, Goldman H, Colle E. Animal model of human disease. Diabetes mellitus. Am J Pathol 1980; 101(2): 485-8.
  • Seemayer TA, Oligny LL, Gartner JG. The Epstein-Barr virus : historical, biologic, pathologic and oncologic considerations. Perspect Pediatr Pathol 1981; 6:1-33.
  • Seemayer TA, Colle E, Tannenbaum GS, Oligny LL, Guttman RD, Goldman H. Spontaneous diabetes mellitus syndrome in the rat III. Pancreatic alterations in aglycosuric and untreated diabetic BB Wistar- derived rats. Metabolism 1983;  32(Suppl. 1):26-32.
  • Oligny LL, Lough J. Hepatic sinusoidal ectasia. Hum Pathol 1992; 23:953-6.
  • Quintal MC, Tabet JC, Oligny LL, Russo P. Oral soft tissue myxoma : report of a case and review of the literature. J Otolaryngol 1994; 23:42-45.
  • Trudel MA, Oligny LL, Caplan S, Caplan C, Schipper HM, Wang E. Statin, a novel marker of nonproliferation. Expression in non-neoplastic lymphoid tissues and follicular lymphomas. Am J Clin Path 1994; 101:421-425.
  • Grignon A, Dubois J, Ouellet MC, Oligny LL, Potier M. Echogenic dilated bowel loops before 21 weeks’ gestation : a new entity. AJR Am J Roentgenol 1997; 168:833-837.
  • Mayer SK, Oligny LL, Deal C, Yazbeck S, Gagné N, Blanchard H. Childhood adrenocortical tumors : case series and reevaluation of prognosis - a 24 year experience. J Pediatr Surg 1997; 32:911-915.
  • Cuffari C, Oligny LL, Seidman E. Dientamoeba fragilis masquerading as allergic colitis. J Pediatr Gastroenterol Nutr 1998; 26:16-20.
  • Lallier M, St-Vil D, Giroux M, Huot C, Gaboury L, Oligny LL, Desjardins JG. Prophylactic thyroidectomy for medullary thyroid carcinoma in gene carriers of MEN2 syndrome. J Pediatr Surg 1998; 33:846-848.
  • Feoli-Fonseca JC, Oligny LL, Filion M, Simard P, Russo PA, Yotov WV. JC9813 – a putative novel human papillomavirus identified by PCR-DS. Biochem Biophys Res Comm 1998; 250:63-67.
  • Feoli-Fonseca JC, Oligny LL, Filion M, Brochu P, Russo PA, Yotov WV. Direct human papillomavirus (HPV) sequencing method yields a novel HPV in a human immunodeficiency virus-positive Quebec woman and distin¬guishes a new HPV clade. J Infect Dis 1998; 178:1492-1496.
  • Wang SP, Marth JD, Oligny LL, Vachon M, Robert MF, Ashmarina L, Mitchell GA. 3-Hydroxy-3-Methylglutaryl-CoA lyase (HL) : gene targeting causes prenatal lethality in HL-deficient mice. Hum Mol Genet 1998; 7: 2057-2062.
  • Guy L, Bégin LR, Oligny LL, Brock GB, Chevalier S, Aprikian AG. Searching for an intrinsic neuroendocrine cell in the kidney. An immunohistochemical study of the fetal, infantile and adult kidney. Pathol Res Pract 1999; 195:25-30.
  • Feoli-Fonseca JC, Oligny LL, Filion M, Brochu P, Simard P, Russo PA, Yotov WV. A two-tier polymerase chain reaction direct sequencing method for detecting and typing human papillomaviruses in pathological speci¬mens. Diagn Mol Pathol 1998; 7:317-323.
  • Feoli-Fonseca JC, Oligny LL, Yotov WV. New method for automatic identification and typing of single and multiple superimposed human papillomavirus sequences. Diagn Mol Pathol 1999; 8:216-221.
  • Wilkin F, Gagné N, Paquette J, Oligny LL, Deal C. Pediatric adrenocortical tumors : molecular events leading to insulin-like growth factor II gene overexpression. J Clin Endocrinol Metab 2000; 85:2048-2056.
  • Mircescu H, Parma J, Huot C, Deal C, Oligny LL, Vassart G, Van Vliet G. Hyperfunctioning malignant thyroid nodule in an eleven-year-old girl : pathological and molecular studies. J Pediatr 2000; 137:585-587.
  • Mircescu H, Wilkins F, Paquette J, Oligny LL, Decaluwe H, Gaboury L, Nolet S, Van Vliet G, Deal C. Molecular characterization of a pediatric pheochromocytoma with suspected bilateral disease. J Pediatr 2001; 138: 269-273.
  • Feoli-Fonseca JC, Oligny LL, Brochu P, Simard P, Falconi S, Yotov WV. Human papillomavirus (HPV) study of 691 pathological specimens from Quebec by PCR-direct sequencing approach. J Med Virol 2001; 63:284-292.
  • Wang SP, Laurin N, Himms-Hagen J, Rudnicki MA, Levy E, Robert MF, Pan L, Oligny LL, Mitchell GA. The adipose tissue phenotype of hormone-sensitive lipase deficiency in mice. Obes Res 2001; 9:119-28.
  • Oligny LL. Human molecular embryogenesis – an overview. Pediatr Dev Pathol 2001; 4: 324-343.
  • Oligny LL, Feoli-Fonseca JC, Brochu P, Simard P, Falconi S, Yotov WV. Human papillomavirus PCR direct sequencing study of cervical precancerous lesions in Quebec children. Sex Transm Infect 2001; 77:391.
  • Oligny LL. Cancer and epigenesis - an overview (article de révision). Annals Diagn Paed Pathol 2001; 5:27-30.
  • Battista MC, Oligny LL, St-Louis J, Brochu M. Intrauterine growth restriction in rats is associated with hypertension and renal dysfunction in adult hood. Am J Physiol Endocrinol Metab 2002; 238:E124-E131.
  • Dancea A, Côté A, Rohlicek C, Bernard C, Oligny LL. Cardiac pathology in sudden unexpected infant death. J Pediatr 2002; 141:336-342.
  • Jolicoeur F, Seemayer TA, Gabbiani G, Robidoux A, Gaboury L, Oligny LL, Schürch W. Multifocal, nascent and invasive myoepithelial carcinoma (malignant myoepithelioma) of the breast : an immunohistochemical and ultra¬structural study. Int J Surg Pathol 2002; 10:281-291.
  • Silva MA, Menezes J, Wizman S, Gendron R, Oligny LL, Seidman EG. Cytokine tissue levels as markers of disease activity in pediatric Crohn disease. Pediatr Res 2003; 54:456-461.
  • Jolicoeur F, Gaboury LA, Oligny LL. Basal cells of second trimester fetal breasts : immunohistochemical study of myoepithelial precursors. Pediatr Dev Pathol 2003; 6:398-413.
  • Robitaille P, Lors H, Dubois J, Rypens F, Oligny LL. A large unilateral renal artery aneurysm in a yound child. Pediatr Radiol 2004; 34:253-5.
  • Oligny LL. Cancer and epigenesis : a developmental perspective. Adv Pediatr 2003; 50:59-80.
  • Jolicoeur F, Gaboury LA, Oligny LL. Basal cells of second trimester fetal breasts : immunohistochemical study of myoepithelial precursors. Pediatr Dev Pathol 2003; 6:398-413.
  • Van Vliet G, Deal CL, Crock PA, Robitaille Y, Oligny LL. Sudden death in growth hormone-treated children with Prader-Willi syndrome. J Pediatr 2004; 144:129-31.
  • Chapdelaine J, Beaunoyer M, St-Vil D, Oligny LL, Garel L, Butter A, Di Lorenzo M. Unilobar congenital pulmonary lymphangiectasis mimicking congenital lobar emphysema : an underestimated presentation? J Pediatr Surg 2004; 39:677-80.
  • Silva MA, Lopez CB, Riverin F, Oligny L, Menezes J, Seidman EG. Characterization and distribution of colonic dendritic cells in Crohn's disease. Inflamm Bowel Dis 2004; 10:504-12.
  • Tesolin M, Lapierre C, Oligny L, Bigras JL, Champagne M. Cardiac metastases from melanoma. Radiographics 2005; 25:249-53.
  • Gorincour G, Rypens F, Grignon A, Garel L, Bortoluzzi P, Oligny L, Lemyre E, Duperron L. Prenatal diagnosis of cloverleaf skull : watch the hands! Fetal Diagn Ther 2005; 20:296-300.
  • Mas E, Alvarez F, Oligny LL, Martin S. Intrahepatic biliary cysts presenting before hepatic portoenterostomy in biliary atresia. J Pediatr Gastroenterol Nutr 2006; 42:440-442.
  • Yzydorczyk C, Gobeil J Fr, Cambonie G, Lahaie I, Le NL, Samarani S, Ahmad A, Lavoie JC, Oligny LL, Pladys P, Hardy P, Nuyt AM. Exaggerated vasomotor response to ANG II in rats with fetal programming of hypertension associated with exposure to a low-protein diet during gestation. Am J Physiol Regul Integr Comp Physiol 2006; 291:R1060-1068.
  • Marcoux D, Nadeau K, McCuaig C, Powell J, Oligny LL. Pediatric anogenital warts: a 7-year review of children referred to a tertiary-care hospital in Montreal, Canada. Pediatr Dermatol 2006; 23:199-207.
  • Bouron-Dal Soglio D, Harvey I, Yazbeck S, Rypens F, Oligny LL, Fournet JC. An association of pleuropulmonary blastoma and cystic nephroma: possible genetic association. Pediatr Dev Pathol 2006; 9:61-64.
  • Bouron-Dal Soglio D, Harvey I, Jovanovic M, Oligny LL, Fournet JC. Bilateral cystic dysplasia of the rete testis with renal adysplasia. Pediatr Dev Pathol 2006; 9:157-160.
  • Rougemont AL, Sartelet H, Oligny L, Bensoussan A, Yazbeck S, Fournet JC. Accessory liver lobe with mesothelial inclusion cysts in an omphalocele: a new malformative association. Pediatr Dev Pathol 2007; Epub, PMID: 17378653.
  • Gorincourt G, Grignon A, Oligny L. A dire finding. Am J Obstet Gynecol 2007; 196:493.

 

4) Abrégés publiés

  • Trudel M, Oligny LL, Caplan S, Caplan C, Schipper H, Wang E. Statin expression in normal and neoplastic hemato-lymphoid cells. Mod Pathol 1991; 4:85A (abrégé #500), [aussi dans Lab Invest 1991, 64:85A, abrégé #500].
  • Oligny LL, Mah RG, Taylor GP. Human Fetal Heart Growth Through Cell Replication : a PCNA Evaluation. Mod Pathol 1993; 6:7P (abrégé #36), [aussi dans Lab Invest 1993; 68:7P, abrégé #36].
  • Kalousek DK, Magee JF, Oligny LL. Cytogenetic analysis of 23 pediatric peripheral neuroectodermal/Askin/Ewing sarcomas. Am J Hum Genet 1993; 53(suppl.), abrégé #1525.
  • Oligny LL, Magee JF, Kalousek DK. Cytogenetic analysis of 250 pediatric mesenchymal and epithelial solid tumors. Am J Hum Genet 1993; 53 (suppl.), abrégé #1530.
  • Oligny LL, Kalousek DK, Magee JF, Fryer C. Prognostic implications of cytogenetic findings in pediatric mesenchymal and epithelial solid tumors. Mod Pathol 1994; 7:7P, abrégé #37, [aussi dans Lab Invest 1994; 70:7P abrégé #37].
  • Oligny LL, Mathers JA, Leung JKW, Magee JF, Kalousek DK, Triche TJ, Sorensen PHB. Ewing's sarcomas : correlation between conventional cytogenetics and molecular genetics. Pediatr Pathol 1995; 15:351-352. Prix Gordon F. Vawter de la Society of Pediatric Pathology.
  • Wang SP, Marth J, Oligny LL, Vachon M, Robert MF, Mitchell GA. HMG CoA Lyase (HL) : Targeted gene disruption in mice causes prenatal lethality in homozygotes. Am J Hum Genet 1995; 57(suppl.):A38, abrégé #190.
  • Oligny LL, Vachon M, Wang SP, Marth J, Robert MF, Mitchell GA. HMG CoA lyase (HL) deficiency is lethal in the embryonic stage of murine development. Mod Pathol 1996; 9:5P, abrégé #23, [aussi dans Lab Invest 1996; 74:5P, abrégé # 23].
  • Lemieux N, Marcoux D, McCuaig C, Milot J, Oligny LL. Focal dermal hypoplasia (Goltz syndrome) : a report of two unusual cases. Am J Human Genet 1996; 59(suppl.):A364, abrégé #2121.
  • Oligny LL, Meyer SK, Deal C, Gagné N, Bensoussan AL, Yazbeck S, Blanchard H : Childhood adrenocortical tumors : case series and re-evaluation of prognosis. Mod Pathol 1997; 10:5P, abrégé #24, [aussi dans Lab Invest 1997; 76:5p, abrégé #24].
  • Gagné N, Paquette J, Oligny LL, Van Vliet G, Deal C. Pediatric adrenocortical tumors : structural DNA abnormalities and insulin-like growth factor-II overexpression as early tumor events. Horm Res 1997; 48(suppl. 2):24, abrégé #92.
  • Aubry MC, Deal C, Oligny LL. Môle partielle (MP), syndrome de Beckwith-Wiedemann (SBW) et 11p15.5 : considérations théoriques. Ann Pathol 1998, 18:72.
  • Oligny LL, Mayer SK, Deal C, Yazbeck S, Gagné N, Blanchard H. Tumeurs corticosurrénaliennes pédiatriques : Revue de la littérature avec réévaluation des critères pronostiques. Ann Pathol 1998; 18:73.
  • Oligny LL, Aubry MC, Deal C. Beckwith-Wiedemann syndrome and partial moles share more than imprinting. Mod Pathol 1998; 11:4P, abrégé #19, [aussi dans Lab Invest 1998; 78:4P, abrégé #19].
  • Oligny LL, Feoli-Fonseca JC, Russo P, Simard P, Brochu P, Yotov WV. Human papilloma virus (HPV) in the pediatric population : diagnosis and typing through PCR-direct sequencing (PCR-DS). Accepté Mod Pathol (aussi dans Lab Invest).
  • Feoli-Fonseca JC, Oligny LL, Brochu P, Simard P, Yotov WV. Human papillomavirus (HPV) study of 482 pathological specimens by PCR-direct sequencing (PCR-DS) approach. Am J Human Genet 1999; 65(suppl.):A-126, abrégé #670).
  • Wang SP, Laurin N, Pan L, Robert MR, Ashmarina M, Oligny LL, Trasler JM, Rudnick MA, Hermo L, Levy E, Mitchell GA. Hormone-sensitive lipase (HSL) is not essential for adipose tissue lipolysis. Am J Human Genet 1999; 65(suppl.):432, abrégé #2449.
  • Oligny LL. Molecular embryogenesis – an overview (reviewed article). Ped and Dev Pathol 2001; 4:324-343.
  • Oligny LL, Feoli-Fonseca JC, Brochu P, Simard P, Falconi S, Yotov WV. Human papillomavirus PCR-direct sequencing study of cervical precancerous lesions in Quebec children. Sex Transm Infect 2001; 77:391.
  • Oligny LL. Cancer and epigenesis – an overview (reviewed article). Annals Diagn Paed Pathol 2001; 5:27-30.
  • Wang SP, Laurin N, Himms-Hagen J, Rudnicki MA, Levy E, Robert MF, Pan L, Oligny LL, Mitchell GA. The adipose tissue phenotype of hormone-sensitive lipase deficiency in mice. Obes Res 2001; 9:119-28.
  • Oligny LL. Cancer and epigenesis – a developmental perspective. Advances in Pediatrics 2002; vol. 50 (invited article).
  • Battista MC, Oligny LL, St-Louis J, Brochu M. Intrauterine growth restriction in rats is associated with hypertension and renal dysfunction. Am J Physiol Endocrinol Metab 2002; 238:E124-E131.
  • Dancea A, Côté A, Rohlicek C, Bernard C, Oligny LL. Cardiac pathology in sudden unexpected infant death. J Pediatr 2002; 141:336-342.
  • Jolicoeur F, Seemayer TA, Gabbiani G, Robidoux A, Gaboury L, Oligny LL, Schürch W. Multifocal, nascent and invasive myoepithelial carcinoma (malignant myoepithelioma) of the breast : an immunohistochemical and ultrastructural study. Int J Surg Pathol 2002; 10:281-291.
  • Jolicoeur F, Gaboury LA, Oligny LL. Basal cells of second trimester fetal breasts : an immunohistochemical study of myoepithelial precursors. Pediatr Dev Pathol, 2003; 6:398-413.
  • Lord H, Dubois J, Rypens F, Oligny LL, Robitaille P. A large unilateral renal artery aneurysm in a young child. Pediatr Radiol, 2004; 34:253-255.
  • Jolicoeur F, Gaboury LA, Oligny LL. Myoepithelial precursors in second trimester fetal breasts. Mod Pathol 2003; 16(1)4P.
  • Jolicoeur F, Oligny LL, Landry C, Soudeyns H, Gaboury LA. Étude de sous-populations myoépithéliales dans le sein. Méd Science 2003; suppl. No 2.
  • Oligny LL, Ducharme S, Gosselin J, Lamoureux J, Boivin C, Fouron JC. A histomorphometric study of normal placentas. Mod Pathol 2005; 18:306 (Résumé # 20).

 


© Département de pathologie et biologie cellulaire, 2014